T. Canceill et al. Analyzing the Clinical Potential of Cold Atmospheric Plasma in Dentistry as an Alternative to Antibiotic Therapy. Comment on Gross et al. Guided Plasma Application in Dentistry – An Alternative to Antibiotic Therapy. Antibiotics

T. Canceill, C. Canal, A. Dubuc, N. Merbahi, S. Cousty. Analyzing the Clinical Potential of Cold Atmospheric Plasma in Dentistry as an Alternative to Antibiotic Therapy. Comment on Gross et al. Guided Plasma Application in Dentistry – An Alternative to Antibiotic Therapy. Antibiotics 2024, 13, 735. Antibiotics 2025, 14, 272. OPEN ACCESS

doi: doi.org/10.3390/antibiotics14030272

Comment

The study by Gross et al. explores the potential of cold atmospheric plasma (CAP) as an alternative to antibiotics in dentistry [1], presenting it as a promising tool to address antimicrobial resistance. This represents a major global public health challenge [2,3], with alarming projections estimating that it could cause up to 10 million deaths annually by 2050 if no effective solutions are implemented [4]. Antibiotic resistance extends far beyond the dental field. Resistance is driven not only by improper prescriptions but also by environmental factors such as antibiotic contamination in water and soil [5]. Thus, public health measures might yield greater benefits than introducing new antimicrobial technologies for localized dental applications.

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To conclude, the findings presented by Gross et al. undoubtedly represent an interesting step forward in exploring the possibility of using cold atmospheric plasmas in dentistry. However, it is essential to approach these results with caution. While the potential of CAP in combating antibiotic resistance is promising, its clinical adoption will require rigorous, long-term research to ensure its safety, efficacy, and practicality.