R. Fraioli et al. Control of stem cell response and bone growth on biomaterials by fully non-peptidic integrin selective ligands. Biomater. Sci.

R. Fraioli, S. Neubauer, F. Rechenmacher, B.M. Bosch, K. Dashnyam, J.H. Kim, R. A. Perez, H.W. Kim, F.J. Gil, M.P. Ginebra, J.M. Manero, H. Kessler, C. Mas-Moruno. Control of stem cell response and bone growth on biomaterials by fully non-peptidic integrin selective ligands. Biomater. Sci., 2019,7, 1281-1285.

doi: 10.1039/c8bm01466c

Abstract

In this communication we report that anchoring αvβ3 or α5β1 integrin-selective RGD peptidomimetics to titanium efficiently tunes mesenchymal stem cell response in vitro and bone growth in rat calvarial defects. Our results demonstrate that this molecular chemistry-derived approach could be successful to engineer instructive coatings for orthopedic applications.