M. Fernandez-Yagüe et al. Enhanced osteoconductivity on electrically charged titanium implants treated by physicochemical surface modifications methods. Nanomedicine: Nanotechnology, Biology, and Medicine

M. Fernández-Yagüe, R. Perez-Antoñanzas, J.J. Roa, M. Biggs, F.J. Gil, M. Pegueroles. Enhanced osteoconductivity on electrically charged titanium implants treated by physicochemical surface modifications methods. Nanomedicine: Nanotechnology, Biology, and Medicine 18 (2019) 1– 10.

doi: doi.org/10.1016/j.nano.2019.02.005

Abstract

Biomimetic design is a key tenet of orthopedic device technology, and in particular the development of responsive surfaces that promote 14 ion exchange with interfacing tissues, facilitating the ionic events that occur naturally during bone repair, hold promise in orthopedic fixation 15 strategies. Non-bioactive nanostructured titanium implants treated by shot-blasting and acid-etching (AE) induced higher bone implant 16 contact (BIC=52% and 65%) compared to shot-blasted treated (SB) implants (BIC=46% and 47%) at weeks 4 and 8, respectively. However, 17 bioactive charged implants produced by plasma (PL) or thermochemical (BIO) processes exhibited enhanced osteoconductivity through 18 specific ionic surface-tissue exchange (PL, BIC= 69% and 77% and BIO, BIC= 85% and 87% at weeks 4 and 8 respectively). Furthermore, 19 bioactive surfaces (PL and BIO) showed functional mechanical stability (resonance frequency analyses) as early as 4 weeks post implantation 20 via increased total bone area (BAT=56% and 59%) ingrowth compared to SB (BAT=35%) and AE (BAT=35%) surfaces.