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Prof. Ginebra's Publications during the last 5 years


  1. Y. Qi, Zh. Ye, Al. Fok, B.N. Holmes, M. Espanol, M.P. Ginebra, C. Aparicio. Effects of Molecular Weight and Concentration of Poly(Acrylic Acid) on Biomimetic Mineralization of Collagen. ACS Biomater. Sci. Eng. DOI: 10.1021/acsbiomaterials.8b00512.

  2. J.M. Sadowska, J. Guillem-Marti, M. Espanol, Ch. Stähli, N. Döbelin, M.P. Ginebra. In vitro response of mesenchymal stem cells to biomimetic hydroxyapatite substrates: A new strategy to assess the effect of ion exchange. Acta Biomater. 2018 Jun 19. pii: S1742-7061(18)30371-4. doi: 10.1016/j.actbio.2018.06.025.

  3. S. Raymond, Y. Maazouz, E.B. Montufar, R.A. Perez, B. González, J. Konka, J. Kaiser, M.P. Ginebra. Accelerated hardening of nanotextured 3D-plotted self-setting calcium phosphate inks. Acta Biomaterialia 75 (2018) 451–462.

  4. J. Guillem-Marti, G. Boix-Lemonche, D. Gugutkov, M.P. Ginebra, G. Altankov, J.M. Manero. Recombinant fibronectin fragment III8-10/polylactic acid hybrid nanofibers enhance the bioactivity of titanium surface. Nanomedicine (Lond). 2018 Apr;13(8):899-912. Epub 2018 Mar 22. doi: 10.2217/nnm-2017-0342

  5. M. Hoyos-Nogués, J. Buxadera-Palomero, M.-P. Ginebra, J.M. Manero, F.X. Gil, C. Mas-Moruno. All-in-one trifunctional strategy: A cell adhesive, bacteriostatic and bactericidal coating for titanium implants. Colloids and Surfaces B: Biointerfaces 169 (2018) 30–40. doi: 10.1016/j.colsurfb.2018.04.050

  6. G. Scionti, L. Rodriguez-Arco, M.T. Lopez-Lopez, A.L. Medina-Castillo, I. Garzón, M. Alaminos, M. Toledano, R. Osorio. Effect of functionalized PHEMA micro- and nano-particles on the viscoelastic properties of fibrin-agarose biomaterials. J Biomed Mater Res A. 2018 Mar;106(3):738-745. doi: 10.1002/jbm.a.36275

  7. C. Lo Porto, F. Palumbo, J. Buxadera-Palomero, C, Canal, P. Jelinek, L. Zajickova, P. Favia. On the plasma deposition of vancomycin-containing nano-capsules for drug-delivery applications. Plasma Process Polym. 2018;e1700232. doi:



  1. A. Barba, A. Diez-Escudero, Y. Maazouz, K. Rappe, M. Espanol, E.B. Montufar, M. Bonany, J.M. Sadowska, J: Guillem-Marti, C. Öhman-Mägi, C. Persson, M.C. Manzanares, J. Franch, M.P. Ginebra. Osteoinduction by Foamed and 3D-Printed Calcium Phosphate Scaffolds: Effect of Nanostructure and Pore Architecture. ACS Appl Mater Interfaces. 2017 Nov 20. doi: 10.1021/acsami.7b14175

  2. M. Hoyos-Nogués, F. Velasco, M.-P. Ginebra, J.M. Manero, F.X. Gil and C. Mas-Moruno. Regenerating bone via multifunctional coatings: the blending of cell integration and bacterial inhibition properties on the surface of biomaterials. ACS Appl Mater Interfaces. 2017 Jul 5;9(26):21618-21630. doi: 10.1021/acsami.7b03127.

  3. Y. Maazouz, E.B. Montufar, J. Malbert, M. Espanol, M.P.Ginebra. Self-hardening and thermoresponsive alpha tricalcium phosphate/pluronic pastes. Acta Biomaterialia 49 (2017) 563-574. doi:

  4. A. Diez-Escudero, M. Espanol, S. Beats, M.P. Ginebra. In vitro degradation of calcium phosphates: effect of multiscale porosity, textural properties and composition. Acta Biomaterialia 60 (2017):81-92. doi:

  5. R. O'Neill, H.O. McCarthy, E. Montufar, M.P. Ginebra, D.I. Wilson, A. Lennon, N. Dunne. Critical Review: Injectability of Calcium Phosphate Pastes and Cements. Acta Biomaterialia 50, 1 March 2017, Pages 1–19. doi:

  6. G. Ciapetti, G. di Pompo, A. Diez-Escudero, E.B. Montufar, M.P. Ginebra S. Avnet, D. Martini, N. Baldini. Osteoclast differentiation from human blood precursors on biomimetic calcium-phosphate substrates. Acta Biomaterialia 50, 1 March 2017, Pages 102–113. doi:

  7. C. Canal, R. Fontelo, I. Hamouda, J. Guillem-Martí, U. Cvelbar, M.P. Ginebra. Plasma-induced selectivity in bone cancer cells death. Free Radical Biology and Medicine 110 (2017) 72-80. doi:

  8. R. Schieber, F. Lasserre, M. Hans, M. Fernández-Yagüe, M. Díaz-Ricart, G. Escolar, M.P. Ginebra, F. Mücklich, M. Pegueroles. Controlled endothelial cell and platelet adhesion onto patterned CoCr alloy surfaces by Direct Laser Interference Patterning technique for cardiovascular applications. Adv Healthc Mater. 2017 Jul 17. doi: 10.1002/adhm.201700327.

  9. A. Diez-Escudero, M. Espanol, X. Lu, C. Persson, M.-P. Ginebra. Heparinization of Beta Tricalcium Phosphate: Osteoimmunomodulatory Effects. Advanced Healthcare Materials, accepted November 2017.

  10. R. Fraioli, P.M. Tsimbouri, L.E. Fisher, A.H. Nobbs, B. Su, S. Neubauer, F. Rechenmacher, H. Kessler, M.P. Ginebra, M.J. Dalby, J.M. Manero, C Mas-Moruno. Towards the cell-instructive bactericidal substrate: exploring the combination of nanotopographical features and integrin selective synthetic ligands. Scientific Reports 7, Article number: 16363 (2017). doi:10.1038/s41598-017-16385-3.

  11. M. Motisuke, G. Mestres, C. O. Renó, R.G. Carrodeguas, C.A.C. Zavaglia, M.P. Ginebra. Influence of Si substitution on the reactivity of α-Tricalcium Phosphate. Materials Science and Engineering C, Volume 75, 1 June 2017, Pages 816-821. doi:

  12. A. Diez-Escudero, M. Espanol, E.B. Montufar, G. Di Pompo, G. Ciapetti, N. Baldini, M.P. Ginebra. Focus ion beam / Scanning electron microscopy characterisation of osteoclastic resorption of calcium phosphate substrates. Tissue Eng Part C Methods. 2017 Feb;23(2):118-124. doi: 10.1089/ten.TEC.2016.0361.

  13. J.M. Sadowska, J. Guillem-Marti, E.B. Montufar, M. Espanol, M.P. Ginebra. Biomimetic versus Sintered Calcium Phosphates: The in vitro Behavior of Osteoblasts and Mesenchymal Stem Cells. Tissue Eng Part A. 2017 Jan 20. doi: 10.1089/ten.TEA.2016.0406.

  14. M.I. Castellanos, J. Guillem-Marti, C. Mas-Moruno, M. Díaz-Ricart, G. Escolar, M.P. Ginebra, F.J. Gil, M. Pegueroles, J.M. Manero. Cell adhesive peptides functionalized on CoCr alloy stimulate endothelialization and prevent thrombogenesis and restenosis. J Biomed Mater Res Part A 2017:00A:000–000. doi: 10.1002/jbm.a.35988.

  15. M.I. Castellanos, C. Mas-Moruno, A. Graua, X. Serra-Picamal, X. Trepat, F. Albericio, M. Joner, F.J. Gil, M.P. Ginebra, J.M. Manero, M. Pegueroles. Functionalization of CoCr surfaces with cell adhesive peptides to promote HUVECs adhesion and proliferation. Applied Surface Science 393 (2017) 82–92. doi:

  16. I. Ajaxon, A. Acciaioli, G. Lionello, M.P. Ginebra, C. Öhman-Mägi, M. Baleani, C. Persson. Elastic properties and strain-to-crack-initiation of calcium phosphate bone cements: revelations of a high-resolution measurement technique. J Mech Behav Biomed Mater. 2017 Oct;74:428-437. doi: 10.1016/j.jmbbm.2017.06.023.

  17. S. Gallinetti, G. Mestres, C. Canal, C. Persson, M.P. Ginebra. A novel strategy to enhance interfacial adhesion in fiber-reinforced calcium phosphate cement. Journal of Mechanical Behaviour of Biomedical Materials 75 (2017) :495-503. doi: 10.1016/j.jmbbm.2017.08.017.

  18. S. Lewin, A. Barba, C. Persson, J. Franch, M.P. Ginebra, C. Öhman-Mägi. Evaluation of bone formation in calcium phosphate scaffolds with μCT-method validation using SEM. Biomed. Mater. 12 (2017) 065005. doi:



  1. Z. Zhao, M. Espanol, J. Guillem-Marti, D. Kempf, A. Diez-Escudero, M.P. Ginebra. Ion-doping as a strategy to modulate hydroxyapatite nanoparticle internalization. Nanoscale, 2016, 8, 1595. doi: 10.1039/c5nr05262a

  2. M. Espanol, G. Mestres, Th. Luxbacher, J.B. Dory, M.P Ginebra. Impact of Porosity and Electrolyte Composition on the Surface Charge of Hydroxyapatite Biomaterials. ACS Appl. Mater. Interfaces, 2016, 8 (1), pp 908–917. doi: 10.1021/acsami.5b10404

  3. R. Fraioli, K. Dashnyam, J.H. Kim, R.A. Perez, H.W. Kim, J. Gil, M.P. Ginebra, J.M. Manero, C. Mas-Moruno. Surface guidance of stem cell behavior: Chemically tailored co-presentation of integrin-binding peptides stimulates osteogenic differentiation in vitro and bone formation in vivo. Acta Biomaterialia 43 (2016) 269–281. doi:

  4. C. Canal, M. Modic, U. Cvelbarc, M.P. Ginebra. Regulating the antibiotic drug release from β-tricalcium phosphate ceramics by atmospheric plasma surface engineering. Biomater. Sci., 2016, 4, 1454. doi: 10.1039/c6bm00411c

  5. C. Canal, K. Khurana, S. Gallinetti, S. Bhatt, J. Pulpytel, F Arefi-Khonsari, M.P. Ginebra. Design of Calcium Phosphate Scaffolds with controlled Simvastatin release by Plasma polymerization. Polymer, v.92, 2016, pp.170-178. doi: 10.1016/j.polymer. 2016.03.069

  6. G. Mestres, K. Kugiejko, D. Pastorino, J.Unosson, C. Öhman, M. Karlsson Ott, M.-P. Ginebra, C. Persson. Changes in the drug release pattern of fresh and set simvastatin-loaded. Materials Science and Engineering C 58(2016) 88-96.

  7. J. Luo, I. Ajaxon, M.P. Ginebra, H. Engqvist, C. Persson. Compressive, diametral tensile and biaxial flexural strength of cutting-edge calcium phosphate cements. Journal of the Mechanical Behavior of Biomedical Materials 60(2016) 617-27. doi: 

  8. M. Hamed Misbah, M. Espanol, L. Quintanilla, M.P. Ginebra, J.C. Rodríguez-Cabello. Formation of calcium phosphate nanostructures under the influence of self-assembling hybrid elastin-like-statherin recombinamers. RSC Adv., 2016, 6, 31225-31234. doi: 10.1039/x0xx00000x.

  9. J. Unosson, E. B. Montufar, H. Engqvist, M.P. Ginebra, C. Persson. Brushite foams - the effect of Tween® 80 and Pluronic® F-127 on foam porosity and mechanical properties. J Biomed Mater Res B Appl Biomater. 2016 Jan;104(1):67-77. doi: 10.1002/jbm.b.33355

  10. C. Labay, J. Buxadera-Palomero, M. Avilés, C. Canal, M.P. Ginebra. Modulation of release kinetics by plasma polymerization of ampicillin-loaded β-TCP ceramics. J. Phys. D: Appl. Phys. 49 (2016) 304004 (10pp). doi:10.1088/0022-3727/49/30/304004

  11. R. O'Neill, E. B. Montufar, M.P. Ginebra, I. Wilson, A. Lennon, N. Dunne. Extent and Mechanism of Phase Separation during the Extrusion of Calcium Phosphate Pastes. Journal of Materials Science. Materials in Medicine, 2016 Feb;27(2):29. doi: 10.1007/s10856-015-5615-z



  1. N. Marín-Pareja, M. Cantini, C. González-García, E. Salvagni, M. Salmerón-Sánchez, M.P. Ginebra. Different Organization of Type I Collagen Immobilized on Silanized and Nonsilanized Titanium Surfaces Affects Fibroblast Adhesion and Fibronectin Secretion. ACS Appl. Mater. Interfaces, 2015, 7 (37), pp 20667-20677. doi 10.1021/acsami.5b05420. ISSN 1944-8244. Impact Factor: 7.145. Q1 25/271 Materials Science, Multidisciplinary; Q1 14/83 Nanoscience & Nanotechnology.

  2. D. Pastorino, C. Canal, M.P. Ginebra. Multiple characterization study on porosity and pore structure of calcium phosphate cements. Acta Biomaterialia (2015) 205-214, doi: 10.1016/j.actbio.2015.09.017

  3. D. Pastorino, C. Canal, M.P. Ginebra. Drug delivery from injectable calcium phosphate foams by tailoring the macroporosity-drug interaction. Acta Biomaterialia 12 (2015):250-9. doi: 10.1016/j.actbio.2014.10.031

  4. Kovtun, M.J. Goeckelmann, A.A. Niclas, E.B. Montufar, M.P. Ginebra, J.A. Planell, M. Santin, A. Ignatius. In vivo performance of novel soybean/gelatin-based bioactive and injectable hydroxyapatite foams. Acta Biomater. 12 (2015): 242-249. doi: 10.1016/j.actbio.2014.10.034

  5. S. Lee, H. Yun, R.A. Perez, S. Gallinetti, M. Ginebra, S. Choi, E. Kim and H. Kim. Nanotopological-Tailored Calcium Phosphate Cements for the Odontogenic Stimulation of Human Dental Pulp Stem Cells through Integrin Signaling. RSC Adv., 2015, 5, 63363. doi: 10.1039/C5RA11564G

  6. E.Cuzmar, R.A. Perez, M.C. Manzanares, M.P.Ginebra, J.Franch. In vivo osteogenic potential of biomimetic hydroxyapatite/collagen microspheres: comparison with injectable cement pastes. PLoS One. 2015 Jul 1;10(7):e0131188. doi: 10.1371/journal.pone.0131188

  7. G. Mestres, M. Espanol, W. Xia, C. Persson, M.P Ginebra, M. Karlsson Ott. Inflammatory Response to Nano and Microstructured Hydroxyapatite. PLoS ONE 10(4): e0120381 (2015). doi:10.1371/journal.pone.0120381

  8. C. Öhman, J. Unosson, E. Carlsson, M.P. Ginebra, C. Persson, H. Engqvist. Porosity prediction of calcium phosphate cements based on chemical composition. J Mater Sci Mater Med. 2015 Jul;26(7):210

  9. E. Fernandez-Garcia, J. Guillem-Marti, C.F. Gutierrez-Gonzalez, A. Fernandez, M.P. Ginebra, S.Lopez-Esteban. Osteoblastic cell response to spark plasma-sintered zirconia/titanium cermets. J Biomater Appl. 2015 Jan;29(6):813-23. doi: 10.1177/0885328214547400

  10. C. Persson, E. Robert, E. Carlsson, C. Robo, A. López, M. Godoy-Gallardo, M.P. Ginebra, H. Engqvist. The effect of unsaturated fatty acid and triglyceride oil addition on the mechanical and antibacterial properties of acrylic bone cements. J Biomater Appl. 2015 Sep;30(3):279-89. doi: 10.1177/0885328215581316

  11. Ajaxon, Y. Maazouz, M.P. Ginebra, C. Öhman, C. Persson. Evaluation of a porosity measurement method for wet calcium phosphate cements. J Biomater Appl. 2015 Nov;30(5):526-36. doi: 10.1177/0885328215594293



  1. Y. Maazouz, E.B. Montufar, J. Guillem-Marti, I. Fleps, C. Öhman, C. Persson, M.P. Ginebra. Robocasting of biomimetic hydroxyapatite scaffolds using self-setting inks. J Mater Chem B. 2014, 2, 5378-86. doi: 10.1039/C4TB00438H

  2. M. Espanol, Z. Zhao, J. Almunia, M.P. Ginebra. Calcium phosphate neuron-like structures: a rare case or a common structure? J. Mater. Chem. B, 2014, 2 (14), 2020-2029. doi: 10.1039/C3TB21524E

  3. E. Veronesi, A. Murgia, A. Caselli, G. Grisendi, M.S. Piccinno, V.Rasini, R. Giordano, T. Montemurro, P. Bourin, L. Sensebè, M.T. Rojewski, H. Schrezenmeier, P. Layrolle, M.P. Ginebra, C. Bunu Panaitescu, E. Gómez-Barrena, F. Catani, P. Paolucci, J.S. Burns, M. Dominici. Transportation Conditions for Prompt Use of Ex-vivo Expanded Freshly Harvested Clinical Grade MSC For Bone Regeneration. Tissue Engineering A 20 (2014) 239-251, doi:10.1089/ten.tec.2013.0250. doi: 10.1089/ten.TEC.2013.0250

  4. N. Marín-Pareja, E. Salvagni, J. Guillem-Marti, C. Aparicio, M.P. Ginebra. Collagen-functionalised titanium surfaces for biological sealing of dental implants: effect of immobilisation process on fibroblasts response. Colloids Surf B Biointerfaces. 2014 Oct 1;122:601-10. doi: 10.1016/j.colsurfb.2014.07.038

  5. E. S. Sanzana, M. Navarro, M. P. Ginebra, J. A. Planell, H. A. Montecinos, A. C. Ojeda, V. A. Contreras. Role of porosity and pore architecture in the in vivo bone regeneration capacity of biodegradable glass scaffolds. J Biomed Mater Res A 102A (2014):1767-73. doi: 10.1002/jbm.a.34845

  6. G. Mestres, F. S. Aguilera, N. Manzanares, R. Osorio, M. Toledano, M.P. Ginebra. Magnesium phosphate cements for endodontic applications with improved long-term sealing ability. International Endodontic Journal, 47, 127-139, 2014. 12123. doi: 10.1111/iej.12123

  7. L. Morejón-Alonso, J.A. Delgado García-Menocal, M. Tarragó Aymerich, J. A. Alvarez Guichard, M. García-Vallés, S. Martínez Manent, M.P. Ginebra. Calcium Phosphate Glasses: Silanation process and effect on the bioactivity behavior of Glass-PMMA composites. J Biomed Mater Res B Appl Biomater. 102(2014):205-13. doi: 10.1002/jbm.b.32996

  8. S. Gallinetti, C. Canal, M. P. Ginebra. Development and Characterization of Biphasic Hydroxyapatite/b-TCP Cements. J. Am. Ceram. Soc., 1-9 (2014). doi:  10.1111/jace.12861

  9. M. Dessì, M.A. Alvarez-Perez, R. De Santis, M.P. Ginebra, J.A. Planell, L. Ambrosio. Bioactivation of calcium deficient hydroxyapatite with foamed gelatin gel. A new injectable self-setting bone analogue. doi: 10.1007/s10856-013-5071-6. J Mater Sci Mater Med 25(2014):283-95. doi: 10.1007/s10856-013-5071-6

  10. C. Canal, S. Gallinetti, M.P. Ginebra. Low pressure plasma treatment of polylactide fibres for enhanced mechanical performance of fibre-reinforced calcium phosphate cements. Plasma Processes and Polymers 11 (2014), 694-703. doi: 10.1002/ppap.201400018

  11. FJ Gil, N. Manzanares, A. Badet, C. Aparicio, MP Ginebra. Biomimetic treatment on dental implants for short -term bone regeneration. Clin Oral Investig. 2014 Jan;18(1):59-66. doi: 10.1007/s00784-013-0953-z

  12. S. Manso, G. Mestres, M.P. Ginebra, N. De Belie, I. Segura, A. Aguado. Development of a low pH cementitious material to enlarge bioreceptivity. Construction and Building Materials 54 (2014): 485-495. doi:10.1016/j.conbuildmat.2014.01.001



  1. C. Canal, D. Pastorino, G. Mestres, Ph. Schuler, M.P. Ginebra. Relevance of microstructure for the early antibiotic release of fresh and pre-set calcium phosphate cements. Acta Biomaterialia 9 (2013) 8403-8412. doi:10.1016/j.actbio.2013.05.016

  2. E.B. Montufar, Y. Maazouz, M.P. Ginebra. Relevance of the setting reaction to the injectability of tricalcium phosphate pastes. Acta Biomaterialia 9 (2013):6188-98. doi: 10.1016/j.actbio.2012.11.028

  3. G. Mestres, M. Abdolhosseini, W. Bowles, S.H. Huang, C. Aparicio, S.U. Gorr, M.P. Ginebra. Antimicrobial properties and dentin bonding strength of magnesium phosphate cements. Acta Biomaterialia 9 (2013):8384-93. doi: 10.1016/j.actbio.2013.05.032

  4. R.A. Pérez, G. Altankov, E. Jorge-Herrero, M.P. Ginebra. Micro- and nanostructured hydroxyapatite-collagen microcarriers for bone tissue engineering applications. Journal of Tissue Engineering and Regenerative Medicine 7 (2013) 353-61. doi: 10.1002/term.530

  5. Rodríguez-Contreras, C. Canal, M. Calafell-Monfor, M.P. Ginebra G. Julio-Mora, M.S. Marqués-Calvo. Methods for the preparation of doxycycline-loaded phb micro- and nano-spheres. European Polymer Journal 49 (2013) 3501-3511. doi: 10.1016/j.eurpolymj.2013.08.010 

  6. Perez, R.A., Kim, T.H., Kim, M., Jang, J.H., Ginebra, M.P., Kim, H.W. Calcium Phosphate Cements Loaded with Basic Fibroblast Growth Factor: Delivery and In Vitro Cell Response. J Biomed Mater Res Part A (2013)101A:923-931. doi: 10.1002/jbm.a.34390

  7. Perez, R.A., Ginebra, M.P. Injectable collagen/?-tricalcium phosphate cement: collagen-mineral phase interactions and cell response. J Mater Sci: Mater Med, (2013) Feb;24(2):381-93. doi: 10.1007/s10856-012-4799-8

You may read Prof. Ginebra's full papers in the web FUTUR (UPC).